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Benign prostatic hyper plasia, an enlargement of the prostate gland is a common disorder among older men. By the age of 85 years, over 90% of men have microscopic prostatic hyper plasia. Clinically, reports suggest that approximately 75% of men over 50 years of age will experience lower urinary tract symptoms (LUTS) suggestive of BPH like difficulty in urinating, urgency, frequency, hesitancy, retention and dribbling. The relationship between BPH and LUTS is complex, since not all men with BPH develop LUTS and not all LUTS are associated with BPH.
BPH can result in severe morbidity as a result of bladder outlet obstruction, with the potential for bladder stones; overflow incontinence, dilation of the upper urinary tract, recurrent urinary infections, gross (prostatic) haematuria and urinary retention. More serious, potentially life threatening complications include urosepsis and renal failure.
BPH is not always associated with acute urinary retention (AUR) and also do not always progress in every patient. However, more recent studies have identified urinary symptoms that are more likely to be associated with BPH that progresses to AUR and thus requires surgical intervention. Patients with greater number of these urinary symptoms may be likely to experience AUR or to require surgery.
Nocturia is a symptom that persons with BPH may consider bothersome. These are many other causes of nocturia such as congestive heart failure, decreased nocturnal release of antidiuretic hormone, recumbency and drinking fluids prior to bed time. All occur commonly in older persons and this symptom can be especially refractory to treatment with either medications or surgery.
Beyond medical complications, BPH and its treatments profoundly affect many daily aspects of life including sexual functioning. However, many men do not ask for medical help despite symptoms that limit these activities. Some elderly men may believe that urinary symptoms and sexual dysfunction are a normal part of aging. This same conclusion might be drawn by younger physicians after noting that prevalence of BPH increases with age. Other patients may be embarrassed about discussing these problems with a healthcare professional, especially if they are concerned that LUTS may be related to sexual function.
Prosteez- An ideal drug for the management of BPH.
The herbomineral formulation, Prosteez, provides an alternative approach, which addresses the gap in the current treatment portfolio, thereby leading to a breakthrough in the management of BPH.
Composition of Prosteez.
Each tablet of Prosteez contains aqueous extracts of the following. Saw palmetto(Serenoa repens) 75mg, Kankola(Piper cubeba) 50 mg, Guduchi (Tinspora cordifolia) 100 mg, Triphala 100 mg, Varuna (Crateva nurvala) 200 mg, Gokshur(Tribulus terrestris) 200 mg, Soya(Glycine soya) 200mg, Kanchanar(Bauhinia variegata) 250 mg, Yashad Bhasma (Zinc compound) 10mg, Shilajit shuddha 25 mg.
Mechanism of Prosteez.
Prosteez acts on multiple levels and its action can be summarized as:
1. Inhibits both type I and type II isoforms of 5α- reductase.
2. Inhibits Dihydrotestosterone (DHT) binding to cytosolic androgen receptors in prostrate cells.
3. Modulates oestrogen activity.
4. Inhibits proliferation of epithelial cells.
5. Induces apoptosis of prostrate cells.
6. Smooth muscle relaxant.
7. Attenuates inflammatory process.
8. Increases force of detrussor muscle contraction.
9. Prostrate specific antioxidant.
Indication of prosteez
Benign Prostatic Hyperplasia (BPH), Stage I & II.
Dosage: 2 tablets orally, twice daily. Please visit www for specific consultation.
Duration: 3 to 6 months.
Contraindications: Contraindicated in advanced BPH with severe urinary retention.
Adverse effects: Well tolerated. Gastro intestinal disturbance occurs rarely, resolved when taken with meals.
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